No association between the presence of periodontal disease and poor IVF outcomes: a pilot study

No association between the presence of periodontal disease and poor IVF outcomes: a pilot study

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Dalia Khalife,1 Ali Khalil,1 Mohamad N Itani,2 Fatin Khalifeh,1 Sara Faour,1 Anastasia Salame,1 Ghina Ghazeeri11Department of Obstetrics & Gynecology, American University of Beirut Medical Center, Beirut, Pyruvate Lebanon; 2Department of Dentistry, American University of Beirut Medical Center, Beirut, LebanonBackground: Periodontal disease can lead to bacteremia with release of cytokines, affecting implantation in women trying to conceive through in vitro fertilization (IVF).A potential association between maternal periodontal disease and poor IVF outcomes has been described.Objective: The aim of the study is to assess whether pre-existing periodontal disease has any effect on IVF parameters.

Method: A pilot study composed of 34 women was conducted at a tertiary care center.Prior to IVF, dental examination, IVF parameters were collected.Results: Thirty-four women participated in the study.

The outcomes of 28 women (82.3%) were analyzed.Out of the 28 patients, 17 patients had a positive pregnancy test (60.

7%) with a total of 13 live births (46.4%) and 4 pregnancy losses (14.3%).

Plaque and bleeding index scores were both lower in patients who achieved pregnancy after IVF yet did not reach statistical significance (p=0.309 and 0.422).

Comparison of mean values for the different infertility parameters showed no significant differences among women with different IVF outcomes (p>0.05).Different degrees of inflammation of the gingiva did not have an effect on the different clinical Tape parameters and the live birth rates.

Conclusion: The evidence provided by the present study does not support the hypothesis.Addressing the status of oral health before any infertility treatment remains to be elucidated.Keywords: periodontal disease, in vitro fertilization, infertility, inflammation, live birth.